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Perl-speaks-NONMEM (PsN) is a collection of Perl modules and programs aiding in the development of non-linear mixed effect models using NONMEM. The functionality ranges from solutions to simpler tasks such as parameter estimate extraction from output files, data file sub setting and resampling, to advanced computer-intensive statistical methods. PsN includes stand-alone tools for the end-user as well as development libraries for method developers. You can read more about the different parts of PsN under Documentation.

Latest news

Version 4.6.0 was released May 23rd 2016, and is available here.

New features in this version include major redesign and extension to sir, a tool for fast and robust assessment of parameter uncertainty with automatically generated visual diagnostics of convergence and parameter confidence intervals, simeval, a tool for simulation-evaluation diagnostics for outlier detection, and benchmark, a tool for simple comparisons of estimation results and approximate run times across combinations of NONMEM options, Fortran compiler and NONMEM versions.

The complete list of new features and bugfixes in 4.6.0 is found here.

  • Mac users need to read this before installing.
  • Installation on Windows: Users who install PsN for the first time need to make sure they install a Perl version where the needed extra modules are available, see instructions on installation page.
  • Click here to open the known bugs wiki with the most recent information regarding known bugs in the latest release.
  • Click here to show change notes for older versions

    More information

    Perl-speaks-NONMEM is copyright
    ©2013-2016 by Mats Karlsson, Andrew Hooker, Rikard Nordgren and Kajsa Harling.
    ©2008-2012 by Mats Karlsson, Niclas Jonsson, Andrew Hooker and Kajsa Harling.
    ©2006-2007 by Lars Lindbom.
    ©2000-2005 by Lars Lindbom and Niclas Jonsson.
    All rights reserved.

    Perl-speaks-NONMEM is free and open source software: you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation, either version 2 of the License, or (at your option) any later version.

    PsN is developed and maintained by Kajsa Harling and Rikard Nordgren .

    PsN was originally developed by Niclas Jonsson and continued by Lars Lindbom for his doctoral thesis. Additional implementation has been done by Pontus Pihlgren, Jakob Ribbing, Kristin Karlsson, Maria Kjellsson and Joakim Nyberg. Additional contributions by Radojka Savic, Paul Baverel, Martin Bergstrand, Elodie Plan, Yasunori Aoki and many more.



    PsN was developed in parts with funding from the DDMoRe and IDeAl projects. NONMEM® is a registered trademark of ICON plc. The Perl camel logo is a registered trademark of O'Reilly Media, Inc. and is used with permission. All logos and trademarks in this site are property of their respective owners.